6. Amyl Nitrate (Poppers)
Amyl nitrate, popularly known as “poppers” (because of the popping sound originally made by crushing the glass receptacle that held the liquid), used to be available for legal purchase in the United States. From 1960 to 1969 it could be obtained without a prescription.
By the end of the 1980s, after a rise in casual use was observed, it was deemed too dangerous and was banned. That said, until very recently it was still widely available in continental European countries such as France, where the dizziness and “rush” associated with it were sought after.
In the UK, poppers can still be bought in stores, usually in drug paraphernalia “head shops.” Online suppliers having circumvented the 1968 ban on their sale for human consumption by marketing them as room deodorizers.
5. Codeine
The pain-relieving drug codeine is a derivative of opium that was first isolated in 1832 by French chemist Pierre Robiquet.
While codeine can be obtained directly from the opium poppy, it is more commonly extracted and synthesized from morphine.
Apparently favorites of late Nirvana frontman Kurt Cobain, cough syrups and cold remedies containing codeine were commonly available without prescription until relatively recently in the United States.
Medicines containing the ingredient can still be found in pharmacies around the world.